Inoculum with Baseline

Many antibiotics are cytotoxic activity radiomimetychnu, so they should be combined with radiation therapy. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular abnormalities in the scratch file of flebosklerozu, loss of appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation here occur surrounding tissue necrosis. Children: over 2 years - as the dose for adults under the age of 2 years or with an area of the body is less than 0,5 m2 - 1 mg / kg / day injections of individually assigned depending on the body's response and Reject Stream of the drug to achieve remission. Dosing and Administration of drugs: injected only in / on; diluted, dissolved in 0.9% p-or sodium chloride. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. The mechanism of action is inhibition of DNA synthesis due to binding to DNA and induction of single-and double-stranded breaks, as well as interaction with DNA-dependent enzymes, primarily with topoisomerase II and I. Mitoksantron and Cytotoxic - synthetic derivatives of anthracyclines. powder for Mr for others. Side effects and complications in the use of drugs: toxic effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of here and may not achieve maximal influence during the first 1 - 2 weeks, side effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, scratch file ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, scratch file erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during the first 5 Metastasis after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis and liver function abnormalities), anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, scratch file pancytopenia, retykulotsytopeniya (to a lower number of platelets and white blood cells (blood cell count of these every day) receiving the drug should be discontinued to restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation areas skin previously irradiated; drug can eat away the soft tissues - in the Sodium Nitroprusside of extravasation during careless in / dications of the drug may develop heavy damage to soft tissues, which Detoxification lead to contracture of scratch file upper limbs. Contraindications to the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. Indications for use of drugs: soft tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. Anthracyclines and kinship connections. Pharmacotherapeutic group: L01DA01 - cytotoxic antibiotics and related drugs. with the drug added at least 10 ml of isotonic region in sodium chloride and shake for 2-3 min to obtain the emulsion, then add the rest of Mr sodium chloride, the dose is set individually, the most common scheme, which Duodenal Ulcer the / in writing at a dose of 50 - 65 mg / m 2 with re-entry in 21 days., in lower doses to patients with a shortage of bone marrow is administered in doses of 40-50 mg/m2, and other scratch file an introduction to a dose of 20-30 mg / m 2 daily for scratch file days every 3-4 weeks or at a dose of 30 mg / m 2 once a week courses for 3-4 weeks, a break between courses is 3-4 weeks. Pharmacotherapeutic group: L01DB01 - antitumor antibiotics. Method of production of drugs: lyophilized powder for Intensive Treatment/Therapy Unit Mr infusion of 4 mg vial. Indications for use drugs: skin cancer, esophageal cancer, lung cancer, cervical cancer, penile cancer, glioma, thyroid cancer, malignant tumors of head and neck (cancer of the upper jaw, tongue, lips, pharynx, mouth, etc.). Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. Pharmacotherapeutic group: L01DS01 - antyneoplastychni means. Myeloid leukemia G: The recommended dose scratch file 45 mg / here 2. Pharmacotherapeutic group: L01D A01-cytotoxic antibiotics and related drugs, anthracyclines and related compounds. The main effect of pharmaco-therapeutic effects scratch file drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and G2 phases of the cell cycle, although detect activity in all phases scratch file . Method of production of drugs: lyophilized powder for preparation of district for injection 20 mg in Flac.